Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. Weakness and tingling can also occur. But weight gain may be a symptom of a side effect called peripheral edema. There arent any studies that have compared these two drugs to each other. Also describe any vitamins, herbs, or supplements you use. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. (Biologic medications are made from living organisms.). Use of the term male in this article refers to sex assigned at birth. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. But theyre each effective in treating osteoporosis and preventing bone loss. This increases your risk for bone fractures. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. All rights reserved. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). If you miss a dose of Prolia, you should receive your injection as soon as you can. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Its given to adults who are at high risk for bone fractures. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. Factors to consider include those in the list below. If youre concerned about hair loss with Prolia, talk with your doctor. They do this by slowing the loss of minerals such as calcium from your bones. Copyright 2023 Elsevier Inc. All Rights Reserved. Call your doctor for medical advice about side effects. Keep out of the reach of children and pets. Special care may be needed. Ask your doctor about the pros and cons of using Prolia. Medically reviewed by Sanjai Sinha, MD. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. And some of these side effects are more common with certain uses of Prolia. Calcium and calcium supplements: Achieving the right With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Dietary calcium is considered safe, but too much calcium in the form of supplements might have some health risks. Our phase IV clinical studies alone cannot establish cause-effect relationship. Prolia side effects: What you should know - Medical But doing so can cause more bone breakdown and increase your risk for bone fractures. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Side effects are possible with Prolia use, but in most cases they go away after a while. Prolia is a monoclonal antibody. Prolia may cause several side effects. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. They can give you more details about this possible side effect and suggest ways to manage it. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. DENOSUMAB (den oh sue mab) slows bone breakdown. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. In rare cases, your doctor may have you self-inject Prolia at home. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures Patients should not stop Prolia treatment without first consulting your WebProlia is used to treat osteoporosis in women after menopause and in men, and in people As you age, your BMD is reduced, and this may increase your risk for osteoporosis. People need calcium for bone health and other functions. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Prolia can cause many serious side effects. With low BMD your bone tissues have less mineral, which means they become weaker. Usually, but it depends. Can diet help improve depression symptoms? Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Osteoporosis treatment: Medications can help - Mayo Clinic What are the possible side effects of Prolia? If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. What should I know about Prolia vs. Reclast? What should I know about Prolia vs. Boniva? Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. For a basic overview of Prolia, including details about its uses, see this article. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Brush and floss your teeth regularly while receiving this medication. To learn more about this, see the How is Prolia administered? section below. Theyll discuss with you other treatments to help protect you from fractures and bone loss. for prostate cancer that has not spread to other parts of the body. These types of medications come in forms that are taken by mouth and forms that are given by injection. This drug may decrease your body's ability to fight infection. If you have any questions about Prolias side effects, talk with your doctor. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. If you are a healthcare professional, click "I Agree" to continue. These can include tingling or numbness in the hands, feet, and face. It is important not to miss your dose. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Nonmetastatic means the cancer hasnt spread to other areas of the body. Its important to practice good oral hygiene during Prolia treatment. generic drugs) are not considered. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Prolia is usually given once every 6 months. Like most drugs, Prolia may cause mild or serious side effects. RA is an autoimmune condition in which your immune system attacks your joints. You can also visit the Prolia manufacturers website to see if they have support options. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Women going through menopause have a higher risk of developing osteoporosis. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. Bring someone with you to your appointment if doing so will help you feel more comfortable. If youd like to learn more about Prolia, talk with your doctor or pharmacist. Prolia should not be used during pregnancy. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. If your levels are high, theyll typically recommend lifestyle changes and medication. Common Try to avoid being around people who are sick. But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Healthline Media does not provide medical advice, diagnosis, or treatment. Is the ketogenic diet right for autoimmune conditions? If youre pregnant or breastfeeding, or considering either, talk with your doctor. Learn more about some of the side effects Prolia may cause. Tell your doctor right away if you become pregnant while taking Prolia. Prolia comes as a solution thats given as an injection under your skin. But certain choices and habits accelerate the process. supplements Youll receive Prolia doses from a healthcare professional. We study millions of patients and 5,000 more each day. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. The fractures may require surgeries, take several months to heal, or both. They can help answer any questions you have about side effects from taking the drug. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. Prolia is a medicine that may affect the ability of your body to fight infections. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Prolia isnt known to cause any harmful interactions with alcohol. 2023 Healthline Media UK Ltd, Brighton, UK. (such as prednisone) for at least six months and are at high risk for fracture. So, dont be afraid to ask questions or offer feedback on your treatment. But its not clear whether this side effect occurred in clinical studies. Studies of Prolia didnt report weight gain as a side effect of the drug. Ask your doctor about your own risk. For example, if you have a serious UTI or other infection, call your doctor right away. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. This is called hypocalcemia. (A low blood calcium level is a possible side effect of Prolia.). or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. They may be able to help you identify the cause. In fact, bone breakdown is higher in the first several months after you stop Prolia. These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Bone pain from Prolia may be most noticeable in your arms and legs. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). Biosimilars usually cost less than brand-name drugs. 2,4. This is because your body doesnt make enough bone, or it loses bone faster than it makes new bone. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. Continue reading, Prolia (denosumab) does increase bone density. Pay special attention to your dental hygiene. These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). Calcium and Vitamin D: Important Ask your plan if they cover the drug, and what the cost will be for you. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. This is not a complete list of warnings for Prolia. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. * Sex and gender exist on spectrums. Amount of calcium needed when taking Prolia Q: Does AlgaePlus Increase Bone Mass? For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Tell your doctor about all other medicines you use. Prolia They can suggest ways to help relieve these side effects. You should also take calcium and vitamin D supplements while being All subjects in the clinical trials of Prolia received 800mg of calcium and Advertising on our site helps support our mission. Patients in the study may take other drugs besides Prolia and Calcium. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. Its used to lower the risk of bone fractures in people with certain other conditions. Because Prolia can also cause low blood calcium, your risk may increase if you receive Prolia. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. Will my fracture risk come back if I stop Prolia treatment? The drug may increase the risk of pregnancy loss. However, drinking too much alcohol may raise your risk of falling. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Prolia Side Effects: Common, Mild, and Serious - Healthline Below, we answer some common questions about taking Prolia. This aids in keeping your calcium level within the recommended range. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. They may give you tips on managing a body weight thats healthy for you. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Prolia injection is a brand of denosumab, which treats osteoporosis. But Zometa contains the active drug zoledronic acid. They can also happen if you have certain conditions or if you take certain medications. Youll receive 60 mg/mL of Prolia once every 6 months. And be sure to let your doctor know about all the medications youre currently taking. Yes, if recommended by your doctor, you can stop taking Prolia. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. And they want you to get the best care possible. Denosumab Injection: MedlinePlus Drug Information The study uses data from the FDA. Prolia injections administered by a healthcare professional. A solid routine can help to strengthen your muscles and bones, which helps to lower your, If you have osteoporosis, diet plays a vital role in managing your condition. Do not treat yourself. Before you start Prolia treatment, your doctor will examine the inside of your mouth. This helps treat osteoporosis by improving bone mass and strengthening your bones. NOTE: This sheet is a summary. Policy. Your doctor can help you decide which drug is better for your needs. No, Prolia isnt a bisphosphonate. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. Calcium has active ingredients of calcium. Heres some information on pregnancy, breastfeeding, and Prolia use. Theyll also usually treat the hypocalcemia right away. Common interactions include nausea among females and fatigue among males. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. See your dentist regularly. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. High cholesterol itself doesnt cause any symptoms. Your low blood calcium must be treated before you receive Prolia. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Instead, it belongs to a different group of medications called biologics. Copyright 1996-2023 Cerner Multum, Inc. If youd like a detailed comparison of Prolia versus Boniva, view this article. You may need to have a negative pregnancy test before starting this treatment. Mild side effects can occur with Prolia use. for breast cancer that has not spread to other parts of the body. There is a potential for serious side effects to an unborn child. Stopping Prolia doesnt cause withdrawal symptoms. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. Prolia Frequently Asked Questions (FAQs) But hair loss has been reported by people who have taken Prolia since then. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. This makes your bones weak and increases your risk for bone fractures or breaks. And some of these side effects are more common with certain uses of Prolia. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Prolia comes with a warning about a low level of calcium in the blood. This medicine may cause jaw bone problems (osteonecrosis). Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Tell your doctor if youd like to know more about these drugs. You should not receive Prolia if you are allergic to denosumab, or if you With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Osteoporosis medications and medication-related osteonecrosis of the jaw. Peripheral edema is a less common side effect that was reported in clinical studies of females* who received Prolia for osteoporosis after menopause.
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